䌀栀愀瀀琀攀爀猀 ㌠ጀ㜀 is dedicated to the human side of the systems picture the yin these chapters e
Báo cáo hóa học: " Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection" pdf
Ngày tải lên :
20/06/2014, 01:20
... with the M2-1 or NP peptide [15] This experimental design allowed us to analyze the dependency of the CD8+ CTL response in the lung and the spleen on the viral context (i .e M2 expressed by RSV versus ... since the effect was observed after infection with each of the three viruses used This point is further validated by the observation that the same epitope expressed by two distinct viruses, RSV ... route), we would expect that any differences in PD-1 expression between the lung and spleen would be present even in naïve mice However, we did not observe a greater frequency of PD-1+ cells or the...
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Semantics Semantics is the study of meaning that is used to understand human expression through language.
Ngày tải lên :
13/07/2014, 23:26
... sentence, the person who executes the action is called AGENT The agent in that sentence is the boy The THEME is the object or person that is directly affected or described by the action In this ... INSTRUMENT He felt sad about cutting his hair When the action is related to a feeling, a state or perception, the agent takes Instrument & experiencer the name of EXPERIENCER The keys are next to the ... properties that the noun phrases have according to their meaning inside the sentence The semantic roles are: Agent Theme Semantic roles Instrument Experiencer Location Source Goal The boy kicked...
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Báo cáo khoa học: Structure of Streptococcus agalactiae serine⁄threonine phosphatase The subdomain conformation is coupled to the binding of a third metal ion pptx
Ngày tải lên :
07/03/2014, 09:20
... clarify the structure solution process – the native data set was ultimately used to derive the structure that we present here (see below) We used the best model we built to the experimental electron ... the beginning of the refinement During refinement, it became apparent that there were differences between the molecules and finally NCS restraints with the default medium weight was applied between ... active site Interestingly, Arg13 now binds a serine residue (Ser155) in the monomer bound to the active site (Fig 3B) This feature might be related to the mechanism of the enzyme (see Discussion)...
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how the use of the diary form narrative is beneficial to the
Ngày tải lên :
21/03/2014, 22:04
... lets a reader feel, and see how characters interpret things themselves The form lets dialogues take place, it lets many people altogether tell a story in first person, and it lets a reader be ... be possible because if one person was telling the whole story, the reader would see and hear what the person telling the story heard and wrote down So using, the diary, Bram Stoker could make ... matter to take place When, there are different people of different places, they can be identified by how they act and how they talk If, Bram Stoker did not use the diary form narrative, this would...
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knots groups and 3-manifolds papers dedicated to the memory of r h fox aug 1975
Ngày tải lên :
11/06/2014, 13:31
... copies the negative side and the positive side of the disk, according as the meridian m enters that side or leaves it Now twist the negative side k full rotations in the direction of - e, and reglue ... invariants of lFSJ, and the ideals are certainly related to the elementary ideals of F in A (see IF]) Furthermore, it is not difficult to determine the range of these invariants, for q < realize any ... Therefore Lemma must be true Now for the proofs of the theorems: Proof of Theorem Let K' ~ Pn(K) and B oc Pn(A n) Then K is the inverse image p;;-l (K') of the completely symmetric fibered knot...
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The Human Side of Animals, by Royal Dixon pdf
Ngày tải lên :
28/06/2014, 19:20
... Between the two, there developed, necessarily, a common language Water-loving 113 animals, like the beavers, seemingly take great pride in their toilets Their fur is always sleek and clean Great ... playing before her humble cave dwelling The sorrow that is felt by the human heart when a beloved one dies is experienced in only a little less degree by an African ape when his mate is shot dead ... away Foxes utter expressive cries which their children know full well The chamois, when frightened, whistle; they might be termed the policemen of the animal world The sentinel will continue a long,...
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Báo cáo y học: "The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G" ppsx
Ngày tải lên :
13/08/2014, 05:22
... have suggested that the major role for Vif in HIV-1 infectivity is to overcome the innate host defence of hA3G [36,37,43,51] We therefore asked whether the antiviral effect of Peptide was dependent ... in the interface of Vif dimers is unknown This underscores the importance of empirically determining whether PPLP is accessible for therapeutic targeting in an infected cell Peptide mimics of the ... Infectivity was monitored by RT activity in each of the cultures at the indicated intervals Peptides were added to the cultures on day one of the infection and every other day as the half-life of...
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research and development effectiveness evaluation model grassroots organization dedicated to the treatment of prisoners in hospitals some provinces - cities 2011-2012
Ngày tải lên :
15/10/2014, 07:58
... guaranteed by the Ministry of Public Security 16 3.2.3 The effectiveness of the model Evaluate the effectiveness of the model based on several criteria: Industrial Service Guarantee detention, examination ... scale Currently, there is no end to online treatment for prisoners So, when the infected subjects beyond the expertise of the clinic will have to transfer to the state hospital in the area to ... city is appropriate At the same time, ensuring the required expertise in areas, treatment rooms reserved for prisoners mainly due to infectious disease department of the hospital because the object...
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Tài liệu Báo cáo khoa học: The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis ppt
Ngày tải lên :
18/02/2014, 08:20
... when expressed ectopically in PC12 neuronal precursor cells cultured on collagen [22] The level of RNF13 expression was not assayed under these conditions We therefore determined whether endogenous ... unable to date to detect the RNF13 ICD in the nucleus There are at least three possible explanations for the absence of detectable RNF13 staining in the nucleus: (a) the PEST domain adjacent to the ... targeting of the protein with the 3· FLAG epitope appeared to be indistinguishable from those of the protein modified with a 1· FLAG epitope inserted after residue 377 (Fig 2) The oligonucleotides described...
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Báo cáo khoa học: MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane ppt
Ngày tải lên :
16/03/2014, 13:20
... which is a lumen The apical side of the retinal pigment epithelium faces the subretinal space The inner and outer segments adjacent to the OLM are the most apical side of photoreceptors and extend ... of elevated levels of MPP5 The levels of MPP3D were well detectable in cells overexpressing MPP3D (lane 9), but coprecipitation of MPP3D with CRB1 could not be detected even when examined on very ... detection levels in retinal lysates Therefore, our data suggests the existence of MPP3–MPP5 complexes but not exclude the existence of MPP3–MPP5–CRB1 complexes at the SAR In 293 cells, MPP3 efficiently...
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Báo cáo hóa học: " Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug " pot
Ngày tải lên :
20/06/2014, 01:20
... dUTPase negative mutants of HSV where virulence was severely affected in mice [10] It is unclear if the observed differences in replication in mice reflect real differences in the biology of these ... contributed to the conception of the studies and the critical review of the manuscript DCQ contributed to the design of the experiments and analysis of the data KAK contributed to the acquisition ... has been deleted Additional experiments are required to resolve this issue and the rabbit model of VV infection and might be a more sensitive indicator of reduced virulence associated with the mutant...
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Báo cáo y học: "Rheumatoid arthritis seropositive for the rheumatoid factor is linked to the protein tyrosine phosphatase nonreceptor 22-620W allele" docx
Ngày tải lên :
09/08/2014, 07:20
... us to estimate the excess of allele sharing expected in R1205 the ASP analysis over the Mendel expectation of 50% Using the estimation of the divergence from Mendel's law obtained from this study ... chi-square test with the appropriate degree of freedom or the Fisher's exact test P < 0.05 was considered significant Linkage-based test in the ASP RA sample [32] Genetic factors are expected to be ... discovered Hence the major interest in genome scan persists, despite the lack of power for some RA genes, such as PTPN22 Interestingly, transmission of the 1858T allele to RF- RA cases precisely...
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Báo cáo khoa học: Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7 pot
Ngày tải lên :
23/03/2014, 13:20
... detailed in the experimental section) The reactions were then subjected to SDS ⁄ PAGE and the gels stained with Coomassie blue to visualize cleavage (B) The more sensitive technique of immunoblotting ... incompletely processed A proportion of caspase-2D1)149 was cleaved to remove the small subunit, thereby permitting detection of the dissociated large subunit The activities of these different forms ... human residue D316 (D333) alone prevented autoprocessing of caspase-2 [17,38] This species difference persisted when the mouse and human mutants were generated using the identical bacterial expression...
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Medical biotechnology including diverse discipline dedicated to improving human health
Ngày tải lên :
15/06/2017, 20:08
... study the safety and efficacy of the new drug Selecting: A new drug is selected for testing on humans only if it either promises to have therapeutic advantages over drugs already in use or is safer ... and gene therapy It mostly focuses on: Disease prevention Disease diagnosis, Disease treatment A disease is a condition that impairs normal bodily functioning Examples of diseases include: heart ... screened eventually becomes an approved drug To screen an antibiotic, it is first placed in a bacterial culture If the antibiotic is effective, it is next tested on infected laboratory animals to...
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Báo cáo khoa học: "Comparing Automatic and Human Evaluation of NLG Systems" potx
Ngày tải lên :
24/03/2014, 03:20
... When multiple reference texts are used, the SE score for a generator forecast is the average of its scores against the reference texts; the SE score for a set of generator forecasts is the average ... write new forecasts texts; we used these as reference texts for the automatic metrics The forecasters created these texts by rewriting the corpus texts, as this was a more natural task for them ... reference summary of n-grams that are matched by the system-generated summary A procedure is applied that averages the score across leave-oneout subsets of the set of reference texts ROUGEN is...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
Ngày tải lên :
18/02/2014, 12:20
... after the start of the reaction, were applied to the DE-81 filters The filters were washed three times for each in mm ammonium formate and once for in water, and the nucleotides were eluted from the ... phosphate compound, and assayed as described for Fig therefore the potential capacity of these compounds for phosphate transfer was compared to those of the other nucleotides The results are presented ... also explain the different elution profiles To further clarify this issue and the effect of enzyme concentration on the oligomerization status, the elution profile of rhTK1 was analyzed under the...
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Báo cáo y học: "The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein" doc
Ngày tải lên :
09/08/2014, 08:23
... osteoblasts with the highest PGE2 levels To determine the mechanism responsible for this shunt between the production of PGE2 and that of LTB4 in OA osteoblasts, we then determined the effect of ... calculated as the ratio of the number of molecules of the target gene to the number of molecules of GAPDH Western blot analysis of cyclooxygenase-2 (COX-2) levels in OA osteoblasts Cell extracts were ... FLAP in the production of LTB4 in these cells and the factors that might modulate their expression We also sought to determine whether there was a relationship between PGE2 levels and either IL-10...
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Báo cáo khoa hoc:" Human MMP28 expression is unresponsive to inflammatory stimuli and does not correlate to the grade of intervertebral disc degeneration" doc
Ngày tải lên :
11/08/2014, 07:21
... was to determine the expression level of MMP28 in traumatic or degenerated discs (with different degrees of degeneration) and to investigate the effects of different concentrations of the proinflammatory ... II), traumatic tissue (removed for the need of spinal fusion after trauma) and severely degenerated IVD tissue However, for both, non-degenerated tissue and the severe degeneration group, high donor-donor ... indicates that compared to other MMPs, MMP28 seems to be rather unresponsive to external inflammatory stimuli in disc cells, although being expressed in degenerative diseases that are characterized...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
Ngày tải lên :
03/11/2012, 10:01
... Selection-based gene targeting places limits on transgene design, due to the need to engineer the requisite selective elements into the transgene Therefore, the ability to conduct gene targeting ... unfeasible for human germline gene therapy Table summarises the key features of the major candidate methods that might serve to achieve human germline gene therapy If human gene transfer technology ... breakage), it seems reasonable to expect sperm cells to be highly resistant to the risk of picking up such molecules [38] Nevertheless, there exists a fairly well established body of empirical...
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